Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease.

ABSTRACT:

Introduction

¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using ¹¹C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET.

Methods

FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB-R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross-sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history.

Results

Metabolism and perfusi

SUBMITTER: Joseph-Mathurin N 

PROVIDER: S-EPMC6215983 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature