Noise-Induced Variability of Immuno-PET with Zirconium-89-Labeled Antibodies: an Analysis Based on Count-Reduced Clinical Images.

ABSTRACT:

Purpose

Positron emission tomography (PET) with Zirconium-89 (Zr-89)-labeled antibodies can be used for in vivo quantification of antibody uptake. Knowledge about measurement variability is required to ensure correct interpretation. However, no clinical studies have been reported on measurement variability of Zr-89 immuno-PET. As variability due to low signal-to-noise is part of the total measurement variability, the aim of this study was to assess noise-induced variability of Zr-89 -immuno-PET using count-reduced clinical images.

Procedures

Data were acquired from three previously reported clinical studies with [⁸⁹Zr]antiCD20 (74 MBq, n = 7), [⁸⁹Zr]antiEGFR (37 MBq, n = 7), and [⁸⁹Zr]antiCD44 (37 MBq, n = 13), with imaging obtained 1 to 6 da

SUBMITTER: Jauw YWS 

PROVIDER: S-EPMC6244539 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature