Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women: a prospective cohort study.

ABSTRACT: BACKGROUND:Some phthalates are endocrine disrupting chemicals used as plasticizers in consumer products, and have been associated with obesity in cross-sectional studies, yet prospective evaluations of weight change are lacking. Our objective was to evaluate associations between phthalate biomarker concentrations and weight and weight change among postmenopausal women. METHODS:We performed cross-sectional (N?=?997) and longitudinal analyses (N?=?660) among postmenopausal Women's Health Initiative participants. We measured 13 phthalate metabolites and creatinine in spot urine samples provided at baseline. Participants' weight and height measured at in-person clinic visits at baseline, year 3, and year 6 were used to calculate body mass index (BMI). We fit multivariable multinomial logistic regression models to explore cross-sectional associations between each phthalate biomarker and baseline BMI category. We evaluated longitudinal associations between each biomarker and weight change using mixed effects linear regression models. RESULTS:In cross-sectional analyses, urinary concentrations of some biomarkers were positively associated with obesity prevalence (e.g. sum of di (2-ethylhexyl) phthalate metabolites [?DEHP] 4th vs 1st quartile OR?=?3.29, 95% CI 1.80-6.03 [p trend

SUBMITTER: Diaz Santana MV 

PROVIDER: S-EPMC6417117 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature