Effect of ranolazine on plasma arginine derivatives and urinary isoprostane 8-iso-PGF_2α in patients with myocardial infarction in the randomized RIMINI-Trial.

ABSTRACT: The purpose of the present study was to assess whether 6-week ranolazine application on top of guideline-based treatment impacts on the arginine/NO pathway and urinary isoprostane 8-iso-PGF_2α as marker of oxidative stress in patients directly after a myocardial infarction. 20 patients with unstable angina pectoris and proof of acute cardiac ischemia entered the study. 10 subjects received the study drug ranolazine in addition to standard treatment, the others received only standard treatment. Urine and venous blood were collected before and after treatment. At the end of the study and compared to baseline, homoarginine levels had increased in the control group. This was not the case in ranolazine-patients. Interestingly, in ranolazine-treated-patients arginine plasma levels were

SUBMITTER: Schwemer TF 

PROVIDER: S-EPMC6450888 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature