Dataset Information

Effect of ranolazine on plasma arginine derivatives and urinary isoprostane 8-iso-PGF_2α in patients with myocardial infarction in the randomized RIMINI-Trial.

ABSTRACT: The purpose of the present study was to assess whether 6-week ranolazine application on top of guideline-based treatment impacts on the arginine/NO pathway and urinary isoprostane 8-iso-PGF_2α as marker of oxidative stress in patients directly after a myocardial infarction. 20 patients with unstable angina pectoris and proof of acute cardiac ischemia entered the study. 10 subjects received the study drug ranolazine in addition to standard treatment, the others received only standard treatment. Urine and venous blood were collected before and after treatment. At the end of the study and compared to baseline, homoarginine levels had increased in the control group. This was not the case in ranolazine-patients. Interestingly, in ranolazine-treated-patients arginine plasma levels were significantly higher at the end of the study than at baseline (difference +26 µmol/L, 95% CI 8.6 to 44 µmol/L). ADMA and SDMA levels were not different. Urine levels of the oxidative stress marker 8-iso-PGF_2α tended to be lower in ranolazine-treated patients (-144 pmol/mg creatinine). Findings of this hypothesis-driven study give evidence that ranolazine treatment enhances arginine plasma levels and lowers oxidative stress.

SUBMITTER: Schwemer TF

PROVIDER: S-EPMC6450888 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Effect of ranolazine on plasma arginine derivatives and urinary isoprostane 8-iso-PGF<sub>2α</sub> in patients with myocardial infarction in the randomized RIMINI-Trial.

Schwemer Tjark F TF Deutscher Navina N Diermann Nadine N Böger Rainer R Schwedhelm Edzard E Blankenberg Stefan S Friedrich Felix W FW

Scientific reports 20190405 1

The purpose of the present study was to assess whether 6-week ranolazine application on top of guideline-based treatment impacts on the arginine/NO pathway and urinary isoprostane 8-iso-PGF<sub>2α</sub> as marker of oxidative stress in patients directly after a myocardial infarction. 20 patients with unstable angina pectoris and proof of acute cardiac ischemia entered the study. 10 subjects received the study drug ranolazine in addition to standard treatment, the others received only standard tr ...[more]

PMID: 30952941

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Dataset Information

Effect of ranolazine on plasma arginine derivatives and urinary isoprostane 8-iso-PGF_2α in patients with myocardial infarction in the randomized RIMINI-Trial.

Publications

Effect of ranolazine on plasma arginine derivatives and urinary isoprostane 8-iso-PGF<sub>2α</sub> in patients with myocardial infarction in the randomized RIMINI-Trial.

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Dataset Information

Effect of ranolazine on plasma arginine derivatives and urinary isoprostane 8-iso-PGF2α in patients with myocardial infarction in the randomized RIMINI-Trial.

Publications

Effect of ranolazine on plasma arginine derivatives and urinary isoprostane 8-iso-PGF<sub>2α</sub> in patients with myocardial infarction in the randomized RIMINI-Trial.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Effect of ranolazine on plasma arginine derivatives and urinary isoprostane 8-iso-PGF_2α in patients with myocardial infarction in the randomized RIMINI-Trial.