Dataset Information

Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population.

ABSTRACT:

Background

Asthma is a complex disorder with multiple phenotypes which can influence its severity and response to treatment. The T_H17 lymphocytes producing IL-17A and IL17-F cytokines, may have a role on asthma inflammation. The aim of our study was to evaluate the association between genetic variants in IL17 pathway genes with asthma and atopy markers.

Materials and methods

Genotyping was performed using a commercial panel in 1245 participants of SCAALA cohort. The study included 91 SNVs in IL-17 pathway genes. Logistic regressions for asthma and atopy markers were performed using PLINK 1.9. In silico analyses were performed using rSNPbase, RegulomeDB, and Gtex portal for in silico gene expression.

Results and discussion

The T allele of rs1974226 in IL17A was positively associated with asthma (OR: 1.37; 95% CI 1.02-1.82). Also, the T allele of rs279548 was positively associated with asthma (OR: 1.30; 95% CI 1.02-1.64), atopy (OR: 1.62; 95% CI 1.05-2.50) and increased expression of the IL17RC in lung and whole blood tissues. The others genetic variants in the IL17 pathways genes were associated with both protection and risk for asthma development as well as with IgE levels.

Conclusion

The genetic variants in IL-17-related genes are associated with the atopic asthma phenotype and IgE production.

SUBMITTER: Silva MJ

PROVIDER: S-EPMC6489266 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population.

Silva Milca de J MJ de Santana Maria B R MBR Tosta Bruna R BR Espinheira Roberta P RP Alcantara-Neves Neuza Maria NM Barreto Maurício L ML Figueiredo Camila Alexandrina CA Costa Ryan Dos S RDS

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20190429

<h4>Background</h4>Asthma is a complex disorder with multiple phenotypes which can influence its severity and response to treatment. The T<sub>H</sub>17 lymphocytes producing IL-17A and IL17-F cytokines, may have a role on asthma inflammation. The aim of our study was to evaluate the association between genetic variants in <i>IL17</i> pathway genes with asthma and atopy markers.<h4>Materials and methods</h4>Genotyping was performed using a commercial panel in 1245 participants of SCAALA cohort. ...[more]

PMID: 31168303

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Dataset Information

Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population.

Background

Materials and methods

Results and discussion

Conclusion

Publications

Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population.

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