Circulating MicroRNAs as potential risk biomarkers for hematoma enlargement after intracerebral hemorrhage.

ABSTRACT:

Background and purpose

MicroRNAs have recently been shown to regulate the downstream bioprocesses of intracerebral hemorrhage. The aim of this study was to investigate whether miRNAs can be used as biomarkers to predict secondary hematoma enlargement (HE) in patients with ICH.

Methods

Consecutively, 79 ICH patients admitted within 6 h of symptom onset and 30 healthy individuals were enrolled in this study. Whole-genome miRNA expression profiles were generated in 32 patients (HE/non-HE: 14/18). Representative differentially expressed miRNAs were measured in all cases (HE/non-HE: 30/49) and normal controls (n = 30) by real-time PCR.

Results

Thirty miRNAs showed differential expressions in the plasma samples from patients with HE as compared with the non-HE controls. Com

SUBMITTER: Zheng HW 

PROVIDER: S-EPMC6493543 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature