Relative effects of LDL-C on ischemic stroke and coronary disease: A Mendelian randomization study.

ABSTRACT:

Objective

To examine the causal relevance of lifelong differences in low-density lipoprotein cholesterol (LDL-C) for ischemic stroke (IS) relative to that for coronary heart disease (CHD) using a Mendelian randomization approach.

Methods

We undertook a 2-sample Mendelian randomization, based on summary data, to estimate the causal relevance of LDL-C for risk of IS and CHD. Information from 62 independent genetic variants with genome-wide significant effects on LDL-C levels was used to estimate the causal effects of LDL-C for IS and IS subtypes (based on 12,389 IS cases from METASTROKE) and for CHD (based on 60,801 cases from CARDIoGRAMplusC4D). We then assessed the effects of LDL-C on IS and CHD for heterogeneity.

Results

A 1 mmol/L higher genetically determined LDL-C

SUBMITTER: Valdes-Marquez E 

PROVIDER: S-EPMC6511103 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature