Mendelian randomization study on the causal effects of tumor necrosis factor inhibition on coronary artery disease and ischemic stroke among the general population.

ABSTRACT:

Background

Tumor necrosis factor (TNF) is a potent inflammatory cytokine that has been causally associated with coronary artery disease (CAD) and ischemic stroke (IS), implying opportunities for disease prevention by anti-TNF therapeutics.

Methods

Leveraging summary statistics of several genome-wide association studies (GWAS), we assessed the repurposing potential of TNF inhibitors for CAD and IS using drug-target Mendelian randomization (MR) design. Pharmacologic blockade of the pro-inflammatory TNF signalling mediated by TNF receptor 1 (TNFR1) was instrumented by four validated variants. Causal effects of TNF/TNFR1 blockade on CAD (N_case/control upto 122,733/424,528) and IS (N_case/control upto 60,341/454,450) were then estimated via various MR estimat

SUBMITTER: Kang X 

PROVIDER: S-EPMC8792065 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature