Apolipoprotein E-ε4 allele predicts escalation of psychotic symptoms in late adulthood.

ABSTRACT:

Background

Research on a putative link between apolipoprotein-ε4 allele (APOE-ε4) and schizophrenia has been inconclusive. However, prior studies have not investigated the association between APOE-ε4 and symptom trajectories, nor has the existing literature taken into account the potentially moderating effect of age in genetic association studies.

Methods

The association between APOE-ε4 and four symptom dimensions was investigated in a longitudinal study of 116 individuals with schizophrenia initially assessed during their first admission for psychosis and evaluated five times over the following 20years. A meta-analysis identified 29 case-control studies of APOE-ε4 allele frequency in schizophrenia, which were analyzed using random-effects meta-regression to test the potenti

SUBMITTER: Jonas K 

PROVIDER: S-EPMC6525644 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature