Longitudinal tau accumulation and atrophy in aging and alzheimer disease.

ABSTRACT:

Objective

To determine the rate of tau accumulation in healthy older adults (OA) and patients with Alzheimer disease (AD), as well as the relationship of tau accumulation to cortical atrophy.

Methods

Two longitudinal flortaucipir (FTP) positron emission tomography (PET) and magnetic resonance imaging (MRI) scans were acquired from 42 OA (21 Pittsburg compound B [PiB]⁺ , age = 77.6 ± 4.6 years, 25 female [F]/17 male [M]) and 19 PiB⁺ patients with AD (age = 63.1 ± 10.3 years, 12 F/7 M) over 1 to 3 years of follow-up. FTP change, structural MRI measures of atrophy, and cross-modal correlations were examined on a voxelwise level. Regional annual percentage change in FTP was also calculated.

Results

Voxelwise FTP change in AD showed the greatest incre

SUBMITTER: Harrison TM 

PROVIDER: S-EPMC6579738 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature