Association of SYNE1 locus with bipolar disorder in Chinese population.

ABSTRACT:

Objectives

Genome-wide association studies (GWAS) suggest that rs9371601 in the SYNE1 gene is a risk SNP for bipolar disorder (BPD) in populations of European ancestry, but further replication analyses across distinct populations are needed.

Methods

We analyzed the association between rs9371601 and BPD in a Han Chinese sample of 1315 BPD cases and 1956 controls.

Results

We observed a significant association between rs9371601 and BPD in Han Chinese (p = 0.0121, OR = 0.859). However, further examinations revealed that the Europeans and Chinese subjects had different BPD risk alleles at the locus. We then found that rs9371601 had different "minor alleles" and distinct linkage disequilibrium (LD) patterns surrounding itself in Europeans and Han Chinese, whic

SUBMITTER: Li W 

PROVIDER: S-EPMC6580462 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature