Randomized Trial of Low-Nicotine Cigarettes and Transdermal Nicotine.

ABSTRACT:

Introduction

A mandated reduction in the nicotine content of cigarettes may decrease smoking, but also increase demand for other nicotine products. The present study tested the impact of smoking cigarettes with very low nicotine content and concurrent use of a transdermal nicotine patch.

Study design

A balanced 2 × 2 factorial randomized clinical trial investigating the impact of cigarette nicotine content (double-blind, very low nicotine content versus normal nicotine content) and use of a transdermal nicotine patch (open label, patch versus no patch).

Setting/participants

Adult daily smokers (n=240) in the Pittsburgh, PA area.

Intervention

Participants were provided with research cigarettes and transdermal nicotine patches (if assigned to patch condition) for

SUBMITTER: Smith TT 

PROVIDER: S-EPMC6756174 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature