Associations of inflammation with frailty in patients with breast cancer aged 50 and over receiving chemotherapy.

ABSTRACT:

Purpose

Chronic inflammation is a significant physiologic feature of frailty; however, its role and clinical utility in cancer-related frailty remains unknown. We sought to determine if pre-chemotherapy inflammation is predictive of frailty after chemotherapy in patients with breast cancer.

Methods

Female patients (N = 144; age ≥ 50) with stage I-III breast cancer scheduled to receive chemotherapy and age-matched non-cancer controls (N = 142) were included in this secondary analysis and assessed pre- and post-chemotherapy. Controls were assessed at equivalent time-points. Frailty was assessed using a modified Fried's score (0-4) using self-reported measures of weakness, exhaustion, walking speed, and physical activity. Serum levels of interleukin (IL) 6, and soluble tumor ne

SUBMITTER: Gilmore N 

PROVIDER: S-EPMC6790284 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature