Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease.

ABSTRACT: Psychosis (delusions or hallucinations) in Alzheimer's disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for schizophrenia, are commonly used in AD + P, suggesting shared mechanisms. Despite this implication, little empirical research has been conducted to examine whether there are mechanistic similarities between AD + P and schizophrenia. In this study, we tested whether polygenic risk score (PRS) for schizophrenia was associated with AD + P. Schizophrenia PRS was calculated using Psychiatric Genomics Consortium data at ten GWAS p value thresholds (P_T) in 3111 AD cases from 11 cohort studies characterized for psychosis using validated, standardized tools. Association between

SUBMITTER: Creese B 

PROVIDER: S-EPMC6805870 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature