Ontology highlight
ABSTRACT:
SUBMITTER: Creese B
PROVIDER: S-EPMC6805870 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Creese Byron B Vassos Evangelos E Bergh Sverre S Athanasiu Lavinia L Johar Iskandar I Rongve Arvid A Medbøen Ingrid Tøndel IT Vasconcelos Da Silva Miguel M Aakhus Eivind E Andersen Fred F Bettella Francesco F Braekhus Anne A Djurovic Srdjan S Paroni Giulia G Proitsi Petroula P Saltvedt Ingvild I Seripa Davide D Stordal Eystein E Fladby Tormod T Aarsland Dag D Andreassen Ole A OA Ballard Clive C Selbaek Geir G
Translational psychiatry 20191022 1
Psychosis (delusions or hallucinations) in Alzheimer's disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for schizophrenia, are commonly used in AD + P, suggesting shared mechanisms. Despite this implication, little empirical research has been conducted to examine whether there are mechanistic similarities between AD + P and schizophrenia. In this study, we tested whether polygenic risk score ...[more]