IL10 haplotypes are associated with diabetic nephropathy susceptibility in patients from western Mexico.

ABSTRACT:

Introduction

Diabetic Nephropathy (DN) is the main cause of chronic kidney disease (CKD) in diabetic patients. An IL-10 imbalance could be related to renal hypertrophy and trigger to nephropathy. Three promoter polymorphisms (-1082G>A, -819C>T, and -592C>A) at IL10 gene have been associated with changes in the IL-10 expression and DN susceptibility. Therefore, the aim of this study was to analyze this association in Mexican patients with DN.

Methods

We conducted a case-control study on 128 patients with DN and 150 control subjects (CS) from western Mexico. All patients were tested for IL10 polymorphisms by PCR-RFLP. Allele frequencies, genotypes, and haplotypes were compared between groups. The significant haplotypes were correlated with patient clinical features.

Results

SUBMITTER: Chavarria-Buenrostro LE 

PROVIDER: S-EPMC6818616 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature