Long-Term Effectiveness of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality in Women and Men: A Randomized Trial.

ABSTRACT:

Background

The long-term effects of sigmoidoscopy screening on colorectal cancer (CRC) incidence and mortality in women and men are unclear.

Objective

To determine the effectiveness of flexible sigmoidoscopy screening after 15 years of follow-up in women and men.

Design

Randomized controlled trial. (ClinicalTrials.gov: NCT00119912).

Setting

Oslo and Telemark County, Norway.

Participants

Adults aged 50 to 64 years at baseline without prior CRC.

Intervention

Screening (between 1999 and 2001) with flexible sigmoidoscopy with and without additional fecal blood testing versus no screening. Participants with positive screening results were offered colonoscopy.

Measurements

Age-adjusted CRC incidence and mortality stratified by sex.

Results

SUBMITTER: Holme O 

PROVIDER: S-EPMC6853067 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature