The impact of fluid balance on outcomes in critically ill near-term/term neonates: a report from the AWAKEN study group.

ABSTRACT:

Background

In sick neonates admitted to the NICU, improper fluid balance can lead to fluid overload. We report the impact of fluid balance in the first postnatal week on outcomes in critically ill near-term/term neonates.

Methods

This analysis includes infants ≥36 weeks gestational age from the Assessment of Worldwide Acute Kidney injury Epidemiology in Neonates (AWAKEN) study (N = 645). Fluid balance: percent weight change from birthweight.

Primary outcome

mechanical ventilation (MV) on postnatal day 7.

Results

The median peak fluid balance was 1.0% (IQR: -0.5, 4.6) and occurred on postnatal day 3 (IQR: 1, 5). Nine percent required MV at postnatal day 7. Multivariable models showed the peak fluid balance (aOR 1.12, 95%CI 1.08-1.17), lowest fluid balance in 1st

SUBMITTER: Selewski DT 

PROVIDER: S-EPMC6941736 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature