A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial.

ABSTRACT:

Introduction

Multinutrient approaches may produce more robust effects on brain health through interactive qualities. We hypothesized that a blood-based nutritional risk index (NRI) including three biomarkers of diet quality can explain cognitive trajectories in the multidomain Alzheimer prevention trial (MAPT) over 3-years.

Methods

The NRI included erythrocyte n-3 polyunsaturated fatty acids (n-3 PUFA 22:6n-3 and 20:5n-3), serum 25-hydroxyvitamin D, and plasma homocysteine. The NRI scores reflect the number of nutritional risk factors (0-3). The primary outcome in MAPT was a cognitive composite Z score within each participant that was fit with linear mixed-effects models.

Results

Eighty percent had at lease one nutritional risk factor for cognitive decline (NRI

SUBMITTER: Bowman GL 

PROVIDER: S-EPMC6944714 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature