CD8⁺T cells from patients with cirrhosis display a phenotype that may contribute to cirrhosis-associated immune dysfunction.

ABSTRACT:

Background

Cirrhosis-associated immune dysfunction (CAID) contributes to high sepsis risk in patients with chronic liver disease. Various innate and; to a lesser extent; adaptive immune dysfunctions have been described as contributors to CAID leading to immune-paresis and impaired anti-microbial response in cirrhosis. In this study, we examined the phenotype of CD8⁺T cells in chronic liver disease with the aim to evaluate changes that might contribute to impaired immune responses.

Methods

Sixty patients with cirrhosis were prospectively recruited for this study. CD8⁺T cells from peripheral blood, ascites and liver explants were characterized using flow cytometry and immunohistochemistry, respectively. The transcriptional signature of flow-sorted HLA-DR<

SUBMITTER: Lebosse F 

PROVIDER: S-EPMC6945243 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature