Epigenetic Changes in Asthma: Role of DNA CpG Methylation.

ABSTRACT: For the past three decades, more than a thousand of genetic studies have been performed to find out the genetic variants responsible for the risk of asthma. Until now, all of the discovered single nucleotide polymorphisms have explained genetic effects less than initially expected. Thus, clarification of environmental factors has been brought up to overcome the 'missing' heritability. The most exciting solution is epigenesis because it intervenes at the junction between the genome and the environment. Epigenesis is an alteration of genetic expression without changes of DNA sequence caused by environmental factors such as nutrients, allergens, cigarette smoke, air pollutants, use of drugs and infectious agents during pre- and post-natal periods and even in adulthood. Three major forms of ep

SUBMITTER: Bae DJ 

PROVIDER: S-EPMC6953489 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature