Gallbladder cancer integrated bioinformatics analysis of protein profile data.

ABSTRACT:

Aim

Identifying the critical genes that differentiate gall bladder cancer from a normal gall bladder and the related biological terms was the aim of this study.

Background

The molecular mechanism underlying gall bladder cancer (GBC) trigger and development still requires investigations. Potential therapeutic biomarkers can be identified through protein-protein interaction network prediction of proteome as a complementary study.

Methods

Here, a literature review of proteomics studies of gall bladder cancer from 2010 to 2019 was undertaken to screen differentially expressed proteins in this cancer. A network of 27 differentially expressed proteins (DEPs) via Cytoscape 3.7.1 and its plug-ins was constructed and analyzed.

Results

Ten proteins were introduced as hub

SUBMITTER: Zali MR 

PROVIDER: S-EPMC7011054 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature