Association of TGF-β1, IL-4, and IL-10 Polymorphisms With Chronic Kidney Disease Susceptibility: A Meta-Analysis.

ABSTRACT:

Background

Anti-inflammatory cytokine polymorphisms in the transforming growth factor-β1 (TGF-β1), interleukin-4 (IL-4), and IL-10 genes have been implicated as risk factors for chronic kidney disease (CKD), but the results from published studies are inconsistent. Our meta-analysis reviews and summarizes the cumulative evidence for these associations.

Methods

A systematic literature search of five databases was performed up to October 2019. Two authors independently extracted data and evaluated the quality of included studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were generated from random-effects or fixed-effects models using Stata 12.0.

Results

Nineteen studies from 10 countries satisfied our inclusion criteria and were in

SUBMITTER: Mai M 

PROVIDER: S-EPMC7056835 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature