The Association of Premorbid Metformin Exposure With Mortality and Organ Dysfunction in Sepsis: A Systematic Review and Meta-Analysis.
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ABSTRACT: Data sources
PubMed and EMBASE (with Medline via Ovid) databases were searched for all studies of premorbid metformin exposure and sepsis published between January 1974 and August 2018.Study selection
Studies of at least 20 patients with sepsis that reported data on metformin use, mortality, and/or organ dysfunction were independently selected.Data extraction
Two reviewers abstracted data on study design, settings, study quality, participants, metformin exposure, mortality, initial lactate levels, and organ dysfunction. Risk of bias was independently assessed.Data synthesis
Eight observational studies fulfilled our criteria, comprising 4,144 patients with sepsis including 562 diabetics on metformin. Premorbid metformin exposure was associated with reduced mortality in sepsis (odds ratio, 0.57; 95% CI, 0.40-0.80). Between studies heterogeneity was low (i 2 = 43%; τ2 = 0.1; p = 0.09). Premorbid metformin exposure was not significantly associated with initial lactate levels (mean difference, 0.39 [-0.50 to 1.28]; i 2 = 72%; p = 0.39).Conclusions
The meta-analysis suggests that premorbid metformin exposure is associated with decreased mortality in sepsis but not with hyperlactatemia. What are the potential mechanisms and whether there is any effect on organ dysfunction remain unclear.
SUBMITTER: Tan K
PROVIDER: S-EPMC7063877 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
The Association of Premorbid Metformin Exposure With Mortality and Organ Dysfunction in Sepsis: A Systematic Review and Meta-Analysis.
Tan Kaiquan K Simpson Andrew A Huang Stephen S Tang Benjamin B Mclean Anthony A Nalos Marek M
Critical care explorations 20190417 4
To examine the association between premorbid metformin exposure and mortality, hyperlactatemia, and organ dysfunction in sepsis.<h4>Data sources</h4>PubMed and EMBASE (with Medline via Ovid) databases were searched for all studies of premorbid metformin exposure and sepsis published between January 1974 and August 2018.<h4>Study selection</h4>Studies of at least 20 patients with sepsis that reported data on metformin use, mortality, and/or organ dysfunction were independently selected.<h4>Data e ...[more]
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