Dynamic cerebral autoregulation: A marker of post-operative delirium?

ABSTRACT:

Objective

We investigated the potential association of cerebral autoregulation (CA) with postoperative delirium (PD), a common complication of cardiac surgery with cardiopulmonary bypass (CPB).

Methods

In patients undergoing coronary artery bypass graft (CABG) surgery with CPB, cerebral blood flow velocity (CBFV) and blood pressure (BP) were continuously recorded during 5-min preoperatively (T1), after 24 h (T2), and 7 days after procedure (T3). Prospective multivariate logistic regression analysis was performed to determine the independent risk factors of PD. Autoregulation index (ARI) was calculated from the CBFV response to a step change in BP derived by transfer function analysis.

Results

In 67 patients, mean age 64.3 ± 9.5 years, CA was depressed at T2 as shown b

SUBMITTER: Caldas JR 

PROVIDER: S-EPMC7106549 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature