Ontology highlight
ABSTRACT:
SUBMITTER: Takizawa T
PROVIDER: S-EPMC7181092 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Takizawa Tsubasa T Qin Tao T Lopes de Morais Andreia A Sugimoto Kazutaka K Chung Joon Yong JY Morsett Liza L Mulder Inge I Fischer Paul P Suzuki Tomoaki T Anzabi Maryam M Böhm Maximilian M Qu Wen-Sheng WS Yanagisawa Takeshi T Hickman Suzanne S Khoury Joseph El JE Whalen Michael J MJ Harriott Andrea M AM Chung David Y DY Ayata Cenk C
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20190626 5
Cortical spreading depolarization (CSD) induces pro-inflammatory gene expression in brain tissue. However, previous studies assessing the relationship between CSD and inflammation have used invasive methods that directly trigger inflammation. To eliminate the injury confounder, we induced CSDs non-invasively through intact skull using optogenetics in Thy1-channelrhodopsin-2 transgenic mice. We corroborated our findings by minimally invasive KCl-induced CSDs through thinned skull. Six CSDs induce ...[more]