Dataset Information

The Relation Between Personality and Biomarkers in Sensitivity and Conversion to Alzheimer-Type Dementia.

ABSTRACT:

Objectives

The present study explored relationships among personality, Alzheimer's disease (AD) biomarkers, and dementia by addressing the following questions: (1) Does personality discriminate healthy aging and earliest detectable stage of AD? (2) Does personality predict conversion from healthy aging to early-stage AD? (3) Do AD biomarkers mediate any observed relationships between personality and dementia status/conversion?

Methods

Both self- and informant ratings of personality were obtained in a large well-characterized longitudinal sample of cognitively normal older adults (N = 436) and individuals with early-stage dementia (N = 74). Biomarkers included amyloid imaging, hippocampal volume, cerebral spinal fluid (CSF) Aβ42, and CSF tau.

Results

Higher neuroticism, lower conscientiousness, along with all four biomarkers strongly discriminated cognitively normal controls from early-stage AD individuals. The direct effects of neuroticism and conscientiousness were only mediated by hippocampal volume. Conscientiousness along with all biomarkers predicted conversion from healthy aging to early-stage AD; however, none of the biomarkers mediated the relationship between conscientiousness and conversion. Conscientiousness predicted conversion as strongly as the biomarkers, with the exception of hippocampal volume.

Conclusions

Conscientiousness and to a lesser extent neuroticism serve as important independent behavioral markers for AD risk.

SUBMITTER: Duchek JM

PROVIDER: S-EPMC7286789 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Publications

The Relation Between Personality and Biomarkers in Sensitivity and Conversion to Alzheimer-Type Dementia.

Duchek Janet M JM Aschenbrenner Andrew J AJ Fagan Anne M AM Benzinger Tammie L S TLS Morris John C JC Balota David A DA

Journal of the International Neuropsychological Society : JINS 20191211 6

<h4>Objectives</h4>The present study explored relationships among personality, Alzheimer's disease (AD) biomarkers, and dementia by addressing the following questions: (1) Does personality discriminate healthy aging and earliest detectable stage of AD? (2) Does personality predict conversion from healthy aging to early-stage AD? (3) Do AD biomarkers mediate any observed relationships between personality and dementia status/conversion?<h4>Methods</h4>Both self- and informant ratings of personalit ...[more]

PMID: 31822309

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Dataset Information

The Relation Between Personality and Biomarkers in Sensitivity and Conversion to Alzheimer-Type Dementia.

Objectives

Methods

Results

Conclusions

Publications

The Relation Between Personality and Biomarkers in Sensitivity and Conversion to Alzheimer-Type Dementia.

Similar Datasets

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