The Relation Between Personality and Biomarkers in Sensitivity and Conversion to Alzheimer-Type Dementia.

ABSTRACT:

Objectives

The present study explored relationships among personality, Alzheimer's disease (AD) biomarkers, and dementia by addressing the following questions: (1) Does personality discriminate healthy aging and earliest detectable stage of AD? (2) Does personality predict conversion from healthy aging to early-stage AD? (3) Do AD biomarkers mediate any observed relationships between personality and dementia status/conversion?

Methods

Both self- and informant ratings of personality were obtained in a large well-characterized longitudinal sample of cognitively normal older adults (N = 436) and individuals with early-stage dementia (N = 74). Biomarkers included amyloid imaging, hippocampal volume, cerebral spinal fluid (CSF) Aβ42, and CSF tau.

Results

Higher neuroticism

SUBMITTER: Duchek JM 

PROVIDER: S-EPMC7286789 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature