Intravenous and oral copper kinetics, biodistribution and dosimetry in healthy humans studied by [⁶⁴Cu]copper PET/CT.

ABSTRACT:

Purpose

Copper is essential for enzymatic processes throughout the body. [⁶⁴Cu]copper (⁶⁴Cu) positron emission tomography (PET) has been investigated as a diagnostic tool for certain malignancies, but has not yet been used to study copper homeostasis in humans. In this study, we determined the hepatic removal kinetics, biodistribution and radiation dosimetry of ⁶⁴Cu in healthy humans by both intravenous and oral administration.

Methods

Six healthy participants underwent PET/CT studies with intravenous or oral administration of ⁶⁴Cu. A 90 min dynamic PET/CT scan of the liver was followed by three whole-body PET/CT scans at 1.5, 6, and 20 h after tracer administration. PET data were used for estimation of hepatic kinetics, biodistrib

SUBMITTER: Kjærgaard K 

PROVIDER: S-EPMC7303253 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature