Association between EFHD2 gene polymorphisms and schizophrenia among the Han population in northern China.

ABSTRACT:

Objective

Schizophrenia is a severe neurodevelopmental disorder with a complex genetic and environmental etiology. The gene encoding EF-hand domain-containing protein D2 (EFHD2) may be a genetic risk locus for schizophrenia.

Methods

We genotyped four EFHD2 single-nucleotide polymorphisms (281 schizophrenia cases [SCZ], 321 controls) from northern Chinese Han individuals using Sanger sequencing and polymerase chain reaction-restriction fragment length polymorphism analysis. Differences existed in genotype, allele, and haplotype frequency distributions between SCZ and control groups.

Results

The rs2473357 genotype and allele frequency distributions differed between SCZ and controls; however, this difference disappeared after Bonferroni correction. Differen

SUBMITTER: Gao M 

PROVIDER: S-EPMC7309398 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature