Association of IGF-1 gene rs2195239 polymorphism with the risk and clinical features of gastric cancer in a Chinese Han population.

ABSTRACT:

Background

Recently, a Japanese study investigated the relationship between insulin-like growth factor-1 (IGF-1) gene rs2195239 polymorphism and gastric cancer (GC) risk and found rs2195239 polymorphism did not relate with the risk of GC. However, no Chinese studies have addressed this relationship until now. Thus, the aims of this study were to demonstrate whether IGF-1 gene rs2195239 polymorphism was linked with the risk and clinical features of GC in a Chinese Han population.

Methods

In order to verify the link between IGF-1 gene rs2195239 polymorphism and GC risk, we recruited 361 GC cases and 418 controls in this case-control study. The genotyping was done by use of a custom-by-design 48-Plex SNP scan TM Kit.

Results

This study found that IGF-1 gene rs2195239 pol

SUBMITTER: Wang P 

PROVIDER: S-EPMC7370715 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature