Fewer tumour-specific PD-1⁺CD8⁺ TILs in high-risk "Infiltrating" HPV^- HNSCC.

ABSTRACT:

Background

The prognosis of HPV^- HNSCC was worse than that of HPV⁺ HNSCC. Analysis of tumours and tumour-infiltrating lymphocytes (TILs) may provide insight into the progression of HPV^- HNSCC.

Methods

The tumour and TIL phenotypic characteristics of 134 HNSCC specimens (HPV^- tumours were classified into "Infiltrating" and "Pushing" subtypes based on their different tumour nest configuration and prognosis) were retrospectively analysed. HNSCC data from the Cancer Genome Atlas (n = 263) were analysed for CD8α, HPV and overall survival (OS). A murine HNSCC model was used to verify the antitumour role of PD-1⁺CD8⁺ TILs.

Results

The "Infiltrating" HPV^- subtype showed shorter OS than the "Pushing"

SUBMITTER: Xu K 

PROVIDER: S-EPMC7492364 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature