[¹⁸F]MPPF and [¹⁸F]FDG μPET imaging in rats: impact of transport and restraint stress.

ABSTRACT:

Background

Stress exposure can significantly affect serotonergic signaling with a particular impact on 5-HT_1A receptor expression. Positron emission tomography (PET) provides opportunities for molecular imaging of alterations in 5-HT_1A receptor binding following stress exposure. Considering the possible role of 5-HT_1A receptors in stress coping mechanisms, respective imaging approaches are of particular interest.

Material and methods

For twelve consecutive days, Sprague Dawley rats were exposed to daily transport with a 1 h stay in a laboratory or daily transport plus 1 h restraint in a narrow tube. Following, animals were subjected to μPET imaging with 2'-methoxyphenyl-(N-2'-pyridinyl)-p-[¹⁸F]fluoro-benzamidoethylpiperazine ([

SUBMITTER: Buchecker V 

PROVIDER: S-EPMC7524912 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature