Early biochemical predictors of survival in intermediate and high-risk prostate cancer treated with radiation and androgen deprivation therapy.

ABSTRACT: BACKGROUND AND PURPOSE:To identify early biochemical predictors of survival in intermediate- and high-risk prostate cancer patients with a pre-treatment PSA <20?ng/mL following definitive radiation therapy (RT) and androgen deprivation therapy (ADT). MATERIALS AND METHODS:A single-institution review of 2566 intermediate and high-risk prostate cancer patients treated with definitive RT and neoadjuvant and concurrent ADT from 1990 to 2012 was performed. The first prostate-specific antigen (PSA) value within three months of ADT initiation (post-ADT PSA) and the first PSA within three months after RT completion (post-RT PSA) were recorded. 1275 had baseline PSA <20?ng/mL and either post-ADT or post-RT PSA available. Median follow-up was 7.6?years. The relationship between post-treatment PSA kinetics and biochemical relapse (BR), distant metastasis (DM), prostate cancer specific death (PCSD) and overall survival (OS) was modeled using Cox regression univariate and multivariate analysis (MVA). RESULTS:MVA demonstrated a strong association between a post-RT PSA ?0.09?ng/mL and a significantly higher risk of BR (HR: 1.93; 95% CI: 1.45-2.57; p?

SUBMITTER: Patel MA 

PROVIDER: S-EPMC7542885 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature