Brain amyloid and the transition to dementia in Down syndrome.

ABSTRACT:

Introduction

Down syndrome (DS) is associated with elevated risk for Alzheimer's disease (AD) due to amyloid beta (Aβ) lifelong accumulation. We hypothesized that the spatial distribution of brain Aβ predicts future dementia conversion in individuals with DS.

Methods

We acquired ¹⁸F-florbetapir positron emission tomography scans from 19 nondemented individuals with DS at baseline and monitored them for 4 years, with five individuals transitioning to dementia. Machine learning classification using an independent test set determined features on ¹⁸F-florbetapir standardized uptake value ratio maps that predicted transition.

Results

In addition to "AD signature" regions including the inferior parietal cortex, temporal lobes, and the cingulum, we foun

SUBMITTER: Keator DB 

PROVIDER: S-EPMC7656170 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature