Intratumoral CD103⁺CD4⁺ T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patients.

ABSTRACT: Our previous study has identified intratumoral CD103⁺CD8⁺ T cells as a favorable prognostic factor in gastric cancer. However, the significance of CD103⁺CD4⁺ T cells in gastric cancer hasn't yet been elucidated. Here, we aimed to investigate the clinical significance and phenotype characteristics of intratumoral CD103⁺CD4⁺ T cells in gastric cancer. In our study, 469 formalin-fixed and paraffin-embedded samples and 24 fresh tissue specimens of patients with gastric cancer from Zhongshan Hospital were included. We manifested that intratumoral CD103⁺CD4⁺ T cells in gastric cancer predicted poor overall survival and inferior responsiveness to fluorouracil-based ACT. The density and phenotypic characteristi

SUBMITTER: Gu Y 

PROVIDER: S-EPMC7714530 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature