Region-specific and dose-specific effects of chronic haloperidol exposure on [³H]-flumazenil and [³H]-Ro15-4513 GABA_A receptor binding sites in the rat brain.

ABSTRACT: Postmortem studies suggest that schizophrenia is associated with abnormal expression of specific GABA_A receptor (GABA_AR) α subunits, including α5GABA_AR. Positron emission tomography (PET) measures of GABA_AR availability in schizophrenia, however, have not revealed consistent alterations in vivo. Animal studies using the GABA_AR agonist [³H]-muscimol provide evidence that antipsychotic drugs influence GABA_AR availability, in a region-specific manner, suggesting a potential confounding effect of these drugs. No such data, however, are available for more recently developed subunit-selective GABA_AR radioligands. To address this, we combined a rat model of clinically relevant antipsychotic drug exposure with

SUBMITTER: Peris-Yague A 

PROVIDER: S-EPMC7731940 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature