Organisational and neuromodulatory underpinnings of structural-functional connectivity decoupling in patients with Parkinson's disease.

ABSTRACT: Parkinson's dementia is characterised by changes in perception and thought, and preceded by visual dysfunction, making this a useful surrogate for dementia risk. Structural and functional connectivity changes are seen in humans with Parkinson's disease, but the organisational principles are not known. We used resting-state fMRI and diffusion-weighted imaging to examine changes in structural-functional connectivity coupling in patients with Parkinson's disease, and those at risk of dementia. We identified two organisational gradients to structural-functional connectivity decoupling: anterior-to-posterior and unimodal-to-transmodal, with stronger structural-functional connectivity coupling in anterior, unimodal areas and weakened towards posterior, transmodal regions. Next, we related spatia

SUBMITTER: Zarkali A 

PROVIDER: S-EPMC7815846 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature