Increased Expression of PD-1 and PD-L1 in Patients With Laryngotracheal Stenosis.

ABSTRACT:

Objectives

Laryngotracheal stenosis (LTS) is a fibrotic condition of the upper airway. Recent evidence suggests dysregulated host immunity plays a role in LTS development and progression. The programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis, targeted by paradigm-shifting immunotherapies for cancer treatment, has also recently been implicated in the pathogenesis of fibrotic pulmonary disease. However, a role for the PD-1/PD-L1 axis in the proximal airway fibrosis seen in LTS patients has not been explored.

Study design

Controlled ex vivo study.

Methods

Expression of PD-1, PD-L1, CD4, and CD8 were evaluated using immunohistochemical staining of cricotracheal resection specimens from postintubation iatrogenic laryngotracheal stenosis (iLTS), idiopathic su

SUBMITTER: Davis RJ 

PROVIDER: S-EPMC7817064 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature