The value of multimodal imaging with ¹²³I-FP-CIT SPECT in differential diagnosis of dementia with Lewy bodies and Alzheimer's disease dementia.

ABSTRACT: Reduced nigrostriatal uptake on N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-[¹²³I]iodophenyl) nortropane (¹²³I-FP-CIT) SPECT reflects dopamine dysfunction, while other imaging markers could be complementary when used together. We assessed how well ¹²³I-FP-CIT SPECT differentiates dementia with Lewy bodies (DLBs) from Alzheimer's disease dementia (ADem) and whether multimodal imaging provides additional value. ¹²³I-FP-CIT SPECT, magnetic resonance imaging, [¹⁸F]2-fluoro-deoxy-D-glucose-positron emission tomography (PET), and ¹¹C-Pittsburgh compound B (PiB)-PET were assessed in 35 participants with DLBs and 14 participants with ADem (autopsy confirmation in 9 DLBs and 4 ADem). Nigrostriatal dopamine transporter uptake was evaluat

SUBMITTER: Miyagawa T 

PROVIDER: S-EPMC7902470 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature