Association between sex hormones regulation-related SNP rs12233719 and lung cancer risk among never-smoking Chinese women.

ABSTRACT:

Background

The mechanism of rapidly increased non-small cell lung cancer (NSCLC) among never-smoking Chinese women has not been elucidated. Ovarian sex steroid hormones have been suggested to counteract lung cancer development, and sex hormone-binding globulin (SHBG) is essential in sex hormones regulation. This study aims to exploring single nucleotide polymorphisms (SNPs) in genomic regions associated with SHBG concentrations that contributed to never-smoking female NSCLC.

Methods

Candidate genes were selected by a genome-wide association (GWAS) meta-analysis and gene expression profiles of never-smoking NSCLC of Chinese women. The candidate SNPs limited to common minor allele frequency (MAF), missense variant, ethnic heterogeneous distribution, and SNPs were genotyped usi

SUBMITTER: Qian Y 

PROVIDER: S-EPMC7940208 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature