Injectable Drug-Releasing Microporous Annealed Particle Scaffolds for Treating Myocardial Infarction.

ABSTRACT: Intramyocardial injection of hydrogels offers great potential for treating myocardial infarction (MI) in a minimally invasive manner. However, traditional bulk hydrogels generally lack microporous structures to support rapid tissue ingrowth and biochemical signals to prevent fibrotic remodeling toward heart failure. To address such challenges, a novel drug-releasing microporous annealed particle (drugMAP) system is developed by encapsulating hydrophobic drug-loaded nanoparticles into microgel building blocks via microfluidic manufacturing. By modulating nanoparticle hydrophilicity and pregel solution viscosity, drugMAP building blocks are generated with consistent and homogeneous encapsulation of nanoparticles. In addition, the complementary effects of forskolin (F) and Repsox (R) on the f

SUBMITTER: Fang J 

PROVIDER: S-EPMC7942842 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature