Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy.
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ABSTRACT:
SUBMITTER: Elliott ML
PROVIDER: S-EPMC8009092 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
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Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy.
Elliott Maxwell L ML Caspi Avshalom A Houts Renate M RM Ambler Antony A Broadbent Jonathan M JM Hancox Robert J RJ Harrington HonaLee H Hogan Sean S Keenan Ross R Knodt Annchen A Leung Joan H JH Melzer Tracy R TR Purdy Suzanne C SC Ramrakha Sandhya S Richmond-Rakerd Leah S LS Righarts Antoinette A Sugden Karen K Thomson W Murray WM Thorne Peter R PR Williams Benjamin S BS Wilson Graham G Hariri Ahmad R AR Poulton Richie R Moffitt Terrie E TE
Nature aging 20210315 3
Some humans age faster than others. Variation in biological aging can be measured in midlife, but the implications of this variation are poorly understood. We tested associations between midlife biological aging and indicators of future frailty-risk in the Dunedin cohort of 1037 infants born the same year and followed to age 45. Participants' Pace of Aging was quantified by tracking declining function in 19 biomarkers indexing the cardiovascular, metabolic, renal, immune, dental, and pulmonary s ...[more]
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