Comorbidity between Alzheimer's disease and major depression: a behavioural and transcriptomic characterization study in mice.

ABSTRACT:

Background

Major depression (MD) is the most prevalent psychiatric disease in the population and is considered a prodromal stage of the Alzheimer's disease (AD). Despite both diseases having a robust genetic component, the common transcriptomic signature remains unknown.

Methods

We investigated the cognitive and emotional behavioural responses in 3- and 6-month-old APP/PSEN1-Tg mice, before β-amyloid plaques were detected. We studied the genetic and pathway deregulation in the prefrontal cortex, striatum, hippocampus and amygdala of mice at both ages, using transcriptomic and functional data analysis.

Results

We found that depressive-like and anxiety-like behaviours, as well as memory impairments, are already present at 3-month-old APP/PSEN1-Tg mutant mice together wi

SUBMITTER: Martin-Sanchez A 

PROVIDER: S-EPMC8017643 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature