Whole-genome sequencing analysis of semi-supercentenarians.
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ABSTRACT:
SUBMITTER: Garagnani P
PROVIDER: S-EPMC8096429 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Whole-genome sequencing analysis of semi-supercentenarians.
Garagnani Paolo P Marquis Julien J Delledonne Massimo M Pirazzini Chiara C Marasco Elena E Kwiatkowska Katarzyna Malgorzata KM Iannuzzi Vincenzo V Bacalini Maria Giulia MG Valsesia Armand A Carayol Jerome J Raymond Frederic F Ferrarini Alberto A Xumerle Luciano L Collino Sebastiano S Mari Daniela D Arosio Beatrice B Casati Martina M Ferri Evelyn E Monti Daniela D Nacmias Benedetta B Sorbi Sandro S Luiselli Donata D Pettener Davide D Castellani Gastone G Sala Claudia C Passarino Giuseppe G De Rango Francesco F D'Aquila Patrizia P Bertamini Luca L Martinelli Nicola N Girelli Domenico D Olivieri Oliviero O Giuliani Cristina C Descombes Patrick P Franceschi Claudio C
eLife 20210504
Extreme longevity is the paradigm of healthy aging as individuals who reached the extreme decades of human life avoided or largely postponed all major age-related diseases. In this study, we sequenced at high coverage (90X) the whole genome of 81 semi-supercentenarians and supercentenarians [105+/110+] (mean age: 106.6 ± 1.6) and of 36 healthy unrelated geographically matched controls (mean age 68.0 ± 5.9) recruited in Italy. The results showed that 105+/110+ are characterized by a peculiar gene ...[more]
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