Low-Dose Tamoxifen for Mammographic Density Reduction: A Randomized Controlled Trial.

ABSTRACT:

Purpose

Tamoxifen prevents breast cancer in high-risk women and reduces mortality in the adjuvant setting. Mammographic density change is a proxy for tamoxifen therapy response. We tested whether lower doses of tamoxifen were noninferior to reduce mammographic density and associated with fewer symptoms.

Patients and methods

Women, 40-74 years of age, participating in the Swedish mammography screening program were invited to the 6-month double-blind six-arm randomized placebo-controlled noninferiority dose-determination KARISMA phase II trial stratified by menopausal status (EudraCT 2016-000882-22). In all, 1,439 women were accrued with 1,230 participants accessible for intention-to-treat analysis. The primary outcome was proportion of women treated with placebo, 1, 2.5, 5, a

SUBMITTER: Eriksson M 

PROVIDER: S-EPMC8189632 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature