Green and efficient synthesis of the radiopharmaceutical [18F]FDOPA using a microdroplet reactor.
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ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC8218909 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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Green and efficient synthesis of the radiopharmaceutical [<sup>18</sup>F]FDOPA using a microdroplet reactor.
Wang Jia J Holloway Travis T Lisova Ksenia K van Dam R Michael RM
Reaction chemistry & engineering 20191213 2
From an efficiency standpoint, microdroplet reactors enable significant improvements in the preparation of radiopharmaceuticals due to the vastly reduced reaction volume. To demonstrate these advantages, we adapt the conventional (macroscale) synthesis of the clinically-important positron-emission tomography tracer [<sup>18</sup>F]FDOPA, following the nucleophilic diaryliodonium salt approach, to a newly-developed ultra-compact microdroplet reaction platform. In this first microfluidic implement ...[more]
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