The ability of post-chemoradiotherapy DWI ADC_mean and ¹⁸F-FDG SUV_max to predict treatment outcomes in head and neck cancer: impact of human papilloma virus oropharyngeal cancer status.

ABSTRACT:

Objectives

To evaluate the ability of post-chemo-radiotherapy (CRT) diffusion-weighted-MRI apparent diffusion coefficient (ADC_mean) and ¹⁸F-FDG PET maximum standardized uptake value (SUV_max) to predict disease-free survival (DFS) in head and neck squamous cell carcinoma (HNSCC), and to determine whether this ability is influenced by human papillomavirus oropharyngeal cancer (HPV-OPC) status.

Methods

This prospective cohort observational study included 65 participants (53 male, mean ± SD age 59.9 ± 7.9 years, 46 HPV-OPC) with stage III or IV HNSCC. Primary tumour and nodal ADC_mean (pre-treatment, 6- and 12-weeks post-CRT) and SUV_max (12-weeks post-CRT) were measured. Variables were compared with 2-year DFS (independent t-

SUBMITTER: Connor S 

PROVIDER: S-EPMC8236463 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature