Dataset Information

The ability of post-chemoradiotherapy DWI ADC_mean and ¹⁸F-FDG SUV_max to predict treatment outcomes in head and neck cancer: impact of human papilloma virus oropharyngeal cancer status.

ABSTRACT:

Objectives

To evaluate the ability of post-chemo-radiotherapy (CRT) diffusion-weighted-MRI apparent diffusion coefficient (ADC_mean) and ¹⁸F-FDG PET maximum standardized uptake value (SUV_max) to predict disease-free survival (DFS) in head and neck squamous cell carcinoma (HNSCC), and to determine whether this ability is influenced by human papillomavirus oropharyngeal cancer (HPV-OPC) status.

Methods

This prospective cohort observational study included 65 participants (53 male, mean ± SD age 59.9 ± 7.9 years, 46 HPV-OPC) with stage III or IV HNSCC. Primary tumour and nodal ADC_mean (pre-treatment, 6- and 12-weeks post-CRT) and SUV_max (12-weeks post-CRT) were measured. Variables were compared with 2-year DFS (independent t-test/Mann-Whitney test) and overall DFS (Cox regression), before and after accounting for HPV-OPC status. Variables were also compared between HPV-OPC and other HNSCC subgroups after stratifying for DFS.

Results

Absolute post-CRT ADC_mean values predicted 2-year DFS and overall DFS for all participants (p = 0.03/0.03, 6-week node; p = 0.02/0.03 12-week primary tumour) but not in the HPV-OPC subgroup. In participants with DFS, percentage interval changes in primary tumour ADC_mean at 6- and 12-weeks were higher in HPV-OPC than other HNSCC (p = 0.01, 6 weeks; p = 0.005, 12 weeks). The 12-week post-CRT SUV_max did not predict DFS.

Conclusion

Absolute post-CRT ADC_mean values predicted DFS in HNSCC but not in the HPV-OPC subgroup. Amongst participants with DFS, post-CRT percentage interval changes in primary tumour ADC_mean were significantly higher in HPV-OPC than in other HNSCC. Knowledge of HPV-OPC status is crucial to the clinical utilisation of post-CRT DWI-MRI for the prediction of outcomes.

SUBMITTER: Connor S

PROVIDER: S-EPMC8236463 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Publications

The ability of post-chemoradiotherapy DWI ADC<sub>mean</sub> and <sup>18</sup>F-FDG SUV<sub>max</sub> to predict treatment outcomes in head and neck cancer: impact of human papilloma virus oropharyngeal cancer status.

Connor S S Sit C C Anjari M M Lei M M Guerrero-Urbano T T Szyszko T T Cook G G Bassett P P Goh V V

Journal of cancer research and clinical oncology 20210622 8

<h4>Objectives</h4>To evaluate the ability of post-chemo-radiotherapy (CRT) diffusion-weighted-MRI apparent diffusion coefficient (ADC<sub>mean</sub>) and <sup>18</sup>F-FDG PET maximum standardized uptake value (SUV<sub>max</sub>) to predict disease-free survival (DFS) in head and neck squamous cell carcinoma (HNSCC), and to determine whether this ability is influenced by human papillomavirus oropharyngeal cancer (HPV-OPC) status.<h4>Methods</h4>This prospective cohort observational study inclu ...[more]

PMID: 34159420

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Dataset Information

The ability of post-chemoradiotherapy DWI ADC_mean and ¹⁸F-FDG SUV_max to predict treatment outcomes in head and neck cancer: impact of human papilloma virus oropharyngeal cancer status.

Objectives

Methods

Results

Conclusion

Publications

The ability of post-chemoradiotherapy DWI ADC<sub>mean</sub> and <sup>18</sup>F-FDG SUV<sub>max</sub> to predict treatment outcomes in head and neck cancer: impact of human papilloma virus oropharyngeal cancer status.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

The ability of post-chemoradiotherapy DWI ADCmean and 18F-FDG SUVmax to predict treatment outcomes in head and neck cancer: impact of human papilloma virus oropharyngeal cancer status.

Objectives

Methods

Results

Conclusion

Publications

The ability of post-chemoradiotherapy DWI ADC<sub>mean</sub> and <sup>18</sup>F-FDG SUV<sub>max</sub> to predict treatment outcomes in head and neck cancer: impact of human papilloma virus oropharyngeal cancer status.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

The ability of post-chemoradiotherapy DWI ADC_mean and ¹⁸F-FDG SUV_max to predict treatment outcomes in head and neck cancer: impact of human papilloma virus oropharyngeal cancer status.