Early genetic diagnosis of clarithromycin resistance in Helicobacter pylori.

ABSTRACT:

Background

The drug resistance rate of clinical Helicobacter pylori (H. pylori) isolates has increased. However, the mechanism of drug resistance remains unclear. In this study, drug-resistant H. pylori strains were isolated from different areas and different populations of Chinese for genomic analysis.

Aim

To investigate drug-resistant genes in H. pylori and find the genes for the early diagnosis of clarithromycin resistance.

Methods

Three drug-resistant H. pylori strains were isolated from patients with gastritis in Bama County, China. Minimal inhibitory concentrations of clarithromycin, metronidazole, and levofloxacin were determined and complete genome sequencing was performed with annotation. Hp1181 and hp1184 gene

SUBMITTER: Li XH 

PROVIDER: S-EPMC8240046 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature