A Bioorthogonal Probe for Multiscale Imaging by ¹⁹F-MRI and Raman Microscopy: From Whole Body to Single Cells.

ABSTRACT: Molecular imaging techniques are essential tools for better investigating biological processes and detecting disease biomarkers with improvement of both diagnosis and therapy monitoring. Often, a single imaging technique is not sufficient to obtain comprehensive information at different levels. Multimodal diagnostic probes are key tools to enable imaging across multiple scales. The direct registration of in vivo imaging markers with ex vivo imaging at the cellular level with a single probe is still challenging. Fluorinated (¹⁹F) probes have been increasingly showing promising potentialities for in vivo cell tracking by ¹⁹F-MRI. Here we present the unique features of a bioorthogonal ¹⁹F-probe that enables direct signal correlation of MRI

SUBMITTER: Chirizzi C 

PROVIDER: S-EPMC8397317 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature