MAT2A-Mediated S-Adenosylmethionine Level in CD4⁺ T Cells Regulates HIV-1 Latent Infection.

ABSTRACT: Antiretroviral drugs effectively halt HIV-1 replication and disease progression, however, due to the presence of a stable viral latent reservoir, the infection cannot be cured by antiretroviral drugs alone. Elucidating the molecular mechanisms underlying HIV-1 latent infection remains a critical hurdle that precludes the development of novel therapeutic strategies aiming for a potential functional cure. Cellular metabolism has been reported to affect HIV-1 replication in CD4⁺ T cells, but it remains largely unclear whether it is involved in the regulation of HIV-1 latency. Here, we performed a sub-pooled CRISPR library knockout screen targeting 1773 metabolic-related genes in a cell model of HIV-1 latent infection and found that Methionine Adenosyltransferase 2A (MAT2A) contribu

SUBMITTER: Yang X 

PROVIDER: S-EPMC8488394 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature