Sulourea-coordinated Pd nanocubes for NIR-responsive photothermal/H₂S therapy of cancer.

ABSTRACT:

Background

Photothermal therapy (PTT) frequently cause thermal resistance in tumor cells by inducing the heat shock response, limiting its therapeutic effect. Hydrogen sulfide (H₂S) with appropriate concentration can reverse the Warburg effect in cancer cells. The combination of PTT with H₂S gas therapy is expected to achieve synergistic tumor treatment.

Methods

Here, sulourea (Su) is developed as a thermosensitive/hydrolysable H₂S donor to be loaded into Pd nanocubes through in-depth coordination for construction of the Pd-Su nanomedicine for the first time to achieve photo-controlled H₂S release, realizing the effective combination of photothermal therapy and H₂S gas therapy.

Results

The Pd-Su nanomedicine shows a high Su loading capacity (85 mg g^-1), a high near-infrared (NIR) photothermal conversion efficiency (69.4%), and NIR-controlled H₂S release by the photothermal-triggered hydrolysis of Su. The combination of photothermal heating and H₂S produces a strong synergetic effect by H₂S-induced inhibition of heat shock response, thereby effectively inhibiting tumor growth. Moreover, high intratumoral accumulation of the Pd-Su nanomedicine after intravenous injection also enables photothermal/photoacoustic dual-mode imaging-guided tumor treatment.

Conclusions

The proposed NIR-responsive heat/H₂S release strategy provides a new approach for effective cancer therapy.

SUBMITTER: Guo X 

PROVIDER: S-EPMC8515682 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature