Sulourea-coordinated Pd nanocubes for NIR-responsive photothermal/H₂S therapy of cancer.

ABSTRACT:

Background

Photothermal therapy (PTT) frequently cause thermal resistance in tumor cells by inducing the heat shock response, limiting its therapeutic effect. Hydrogen sulfide (H₂S) with appropriate concentration can reverse the Warburg effect in cancer cells. The combination of PTT with H₂S gas therapy is expected to achieve synergistic tumor treatment.

Methods

Here, sulourea (Su) is developed as a thermosensitive/hydrolysable H₂S donor to be loaded into Pd nanocubes through in-depth coordination for construction of the Pd-Su nanomedicine for the first time to achieve photo-controlled H₂S release, realizing the effective combination of photothermal therapy and H₂S gas therapy.

Results

The Pd-Su nanomedicine shows

SUBMITTER: Guo X 

PROVIDER: S-EPMC8515682 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature